Calcium Folinate Leucovorin Calcium 99% Powder CAS 1492-18-8

Hot Sales Product Calcium folinate is the antidote of folic acid antagonists. This Active Pharmaceutical Ingredients is a formylated derivative of folic acid. Its effect is similar to that of folic acid. It is the activated form of folic acid in vivo. After entering the human body, calcium folinate is transformed into tetrahydrofolate by tetrahydrofolate reductase, which can effectively resist the toxic reaction caused by methotrexate. Calcium folinate can "rescue" the toxic reaction of excessive folic acid antagonists in vivo, is conducive to the synthesis of Thymine Nucleotides, DNA, RNA and even proteins, and can stimulate the growth and maturation of leukocytes. This Medicine Raw Material can limit the damage of methotrexate to normal cells, reverse the reaction of methotrexate to bone marrow and gastrointestinal mucosa through mutual competition, but has no effect on the existing neurotoxicity of methotrexate. It is mainly used as an antidote for folic acid antagonists (such as methotrexate, methotrexate, phenytoin sodium, phenobarbital, pyrimidine or trimethoprim).  It also can be used as Anti-Cancer Ingredients, and Health Care Materials.

Product Name: Calcium folinate

Appearance: Light yellow to off white powder

Cas No.:1492-18-8

M.F.: C20H25CaN7O7

M.W.: 515.54

 

1. It is mainly used as an antidote for folic acid antagonists (such as methotrexate, pyrimidine or trimethoprim).

2. It is used to prevent serious toxic effects caused by methotrexate overdose or high-dose treatment.

3. Megaloblastic anemia caused by folic acid deficiency.

4. It is used in combination with fluorouracil in the treatment of advanced colorectal cancer.

When oral folic acid is ineffective, it is used for stomatitis diarrhea, malnutrition, megaloblastic anemia caused by pregnancy or infancy and leukopenia.But it is not suitable for vitamin B12 deficiency anemia.The combination of fluorouracil and folic acid can prolong the survival period of colorectal cancer in recent years.

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