Medicine Raw Material Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turnstimulates insulin production. Glyburide (Glibenclamide) is an ATP-dependent K+ channel (KIR6, KATP) and CFTR Cl- channel blocker.This compound inhibits recombinant CFTR Cl- channels. This Active Pharmaceutical Ingredients is mainly used asDepressing Blood-Fat Ingredients, and Decrease Blood Sugar Ingredients.
[Product Name]:Glibenclamide
[Appearance]: White or almost white crystalline powder
[Specification]: 99%
[Test Method]: HPLC
[Cas No.]: 10238-21-8
[M.F.]: C23H28ClN3O5S
[M.W.]: 494
[Solubility]:Practically insoluble in water, sparingly soluble in methylene chloride, slightly soluble in ethanol (96%) and in methanol. Practically insoluble in ether. It dissolves in dilute solutions of alkali hydroxides.
1. Hypoglycemic drugs, for the treatment of mild, non insulin dependent diabetes;
2. Glibenclamide belongs to the second generation oral sulfonylurea drugs, with the mechanism of tolbutamide, its hypoglycemic effect is the strongest sulfonylurea, intensity for tolbutamide 200 ~ 250 times. Be selective effect on pancreatic beta cells, promote the secretion of insulin, can enhance the hypoglycemic effect of exogenous insulin, insulin receptor after strengthening effect;
3. Glibenclamide is one of the drugs currently used to treat type 2 diabetes, the most often used, because the utility function is fast and strong, so after the application has obvious effect, can effectively control blood sugar, high blood sugar etc.
1. Hypoglycemic drugs, for the treatment of mild, non insulin dependent diabetes.
2. Glibenclamide belongs to the second generation oral sulfonylurea drugs, with the mechanism of tolbutamide, its hypoglycemic effect is the strongest sulfonylurea, intensity for tolbutamide 200 ~ 250 times. Be selective effect on pancreatic beta cells, promote the secretion of insulin, can enhance the hypoglycemic effect of exogenous insulin, insulin receptor after strengthening effect.
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